The apparatus consists of a separator which contains a hydrophobic PTFE membrane sandwiched between two halves of a separator chip. In flow, the liquid-liquid extraction apparatus allows the setting of both the system pressure and CMP. Both the overall system pressure and the cross membrane pressure (CMP) present in the separator section of the apparatus.
The principles of liquid-liquid extraction in flow are based on the immiscibility of the organic and aqueous phases along with the fluid pressure. Both phases can then be fed into separate fluid lines which can go onto collection, waste or fed through for further reactions (multi-step synthesis). The separation of the phases is promoted by the cross-membrane pressure which forces the organic phase through the hydrophobic membrane. In flow chemistry, work-up and subsequent separation of an organic and aqueous phase can be conducted by flowing the input stream across a hydrophobic membrane. Liquid-liquid Extraction is a purification technique that is used in work-up to separate compounds based on their relative solubilities in two immiscible solvents. Liquid-liquid extraction is a purification technique that is used in work-up to separate compounds based on their relative solubilities in two immiscible solvents.
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